Risk of Hemorrhagic Transformation with Early Use of Direct Oral Anticoagulants after Acute Ischemic Stroke: A Pooled Analysis of Prospective Studies and Randomized Trials.
Anas AlrohimiDavid Z RoseWilliam Scott BurginSwetha RenatiNicholas HilkerWei DengGuilherme OliveiraTheresa BeckieArthur J LabovitzMichael G FradleyNhi TranLaura C GioiaMahesh KateKuan H NgDariush DowlatshahiThalia Shoshana FieldShelagh B CouttsMuzzafar SiddiquiMichael D HillJodi MillerGlen C JicklingAshfaq ShuaibBrian BuckMukul SharmaKenneth ButcherPublished in: International journal of stroke : official journal of the International Stroke Society (2023)
In this pooled analysis, initiation of DOAC within 48 hours post-stroke was not associated with increased incident risk of HT, and none developed symptomatic HT. The analysis was underpowered to determine the effect of early DOAC use upon recurrent ischemic events.