Photoredox-Catalyzed and Silane-Mediated Hydrofluoromethylation of Unactivated Alkenes with Fluoroiodomethane in Water.
Chen-Chen HuChao-Lai TongYu-Yang ZhangXiu-Hua XuFeng-Ling QingPublished in: Organic letters (2023)
The first hydrofluoromethylation of unactivated alkenes with fluoroiodomethane and hydrosilanes is developed by merging photoredox catalysis and silane-mediated deiodination processes. The key to the success of this reaction is the use of water as the solvent to enhance the activity of CH 2 F radical toward unactivated alkenes.