Cerebrospinal Fluid Bacillary Load by Xpert MTB/RIF Ultra Polymerase Chain Reaction Cycle Threshold Value Predicts 2-Week Mortality in Human Immunodeficiency Virus-Associated Tuberculous Meningitis.
Emily M MartynAnanta S BangdiwalaEnock KagimuMorris K RutakingirwaJohn KasibanteMichael OkirwothGavin SteadVincent WaddaMatthew F PullenTyler D BoldDavid B MeyaDavid R BoulwareNathan C BahrFiona V CresswellPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2021)
High CSF TB bacillary load, as measured by Xpert Ultra Ct tertile, is associated with an almost 2-fold higher 2-week mortality in HIV-associated TBM and is a better predictor than the reported Xpert Ultra semi-quantitative category. Xpert Ultra Ct values could identify TBM patients at increased risk of death who may benefit from enhanced supportive care.
Keyphrases
- human immunodeficiency virus
- high resolution
- cerebrospinal fluid
- antiretroviral therapy
- hepatitis c virus
- cardiovascular events
- hiv infected
- mycobacterium tuberculosis
- hiv aids
- hiv positive
- contrast enhanced
- healthcare
- pulmonary tuberculosis
- computed tomography
- image quality
- dual energy
- hiv testing
- positron emission tomography
- risk factors
- pet ct
- quality improvement
- coronary artery disease
- type diabetes
- health insurance
- pain management
- mass spectrometry
- affordable care act