Abacavir causes leukocyte/platelet crosstalk by activating neutrophil P2X7 receptors thus releasing soluble lectin-like oxidized low-density lipoprotein receptor-1.

Maria Amparo Blanch-RuízAinhoa Sánchez-LópezCésar Ríos-NavarroRaquel Ortega-LunaVíctor Collado-DíazSamuel OrdenMaría Angeles Martínez-CuestaJuan V EspluguesÁngeles Álvarez

Published in: British journal of pharmacology (2022)

Neutrophils are target cells in abacavir-induced thrombosis. Abacavir released sLOX-1 from neutrophils via activation of their P2X7 receptors, which in turn activated platelets. Hence, sLOX-1 could be the missing link in the cardiovascular risk associated with abacavir.

Keyphrases

low density lipoprotein
induced apoptosis
signaling pathway
cell cycle arrest
diabetic rats
high glucose
living cells
fluorescent probe
endoplasmic reticulum stress
cell proliferation
cell death
sensitive detection
red blood cell