β-2-himachalen-6-ol protects against skin cancer development in vitro and in vivo.

Hamid E DaaboulCostantine F DaherRobin I TalebJoelle BoulosKikki Bodman-SmithPetra BoukampWassim N ShebabyCarol DagherMirvat El-SibaiMohamad A Mroueh

Published in: The Journal of pharmacy and pharmacology (2017)

In conclusion, HC treatment induced cell cycle arrest (low dose) and promoted apoptosis partly via inhibition of the MAPK/ERK and PI3K/AKT pathways with no significant toxicity to laboratory mice.

Keyphrases

pi k akt
cell cycle arrest
signaling pathway
skin cancer
low dose
cell proliferation
cell death
oxidative stress
diabetic rats
high glucose
high fat diet induced
type diabetes
adipose tissue
endothelial cells
insulin resistance
replacement therapy
skeletal muscle
stress induced