Elinzanetant (NT-814), a Neurokinin 1,3 Receptor Antagonist, Reduces Estradiol and Progesterone in Healthy Women.

Steve PawseyEdouard Gregory MillsElizabeth BallantyneKirsteen DonaldsonMary KerrMike TrowerWaljit Singh Dhillo

Published in: The Journal of clinical endocrinology and metabolism (2021)

NK1,3 receptor antagonism with elinzanetant dose-dependently suppressed the reproductive axis in healthy women, with the 120-mg dose lowering estradiol to potentially ideal levels for UFs and EM. As such, elinzanetant may represent a novel therapy to manipulate reproductive hormone levels in women with hormone-driven disorders.

Keyphrases

estrogen receptor
polycystic ovary syndrome
stem cells
type diabetes
pregnancy outcomes
bone marrow
mesenchymal stem cells
pregnant women