Can the diameter of nerve fibers be effectively utilized to enhance the accuracy of determining the length of the aganglionic segment compared to intraoperative biopsy in patients with Hirschsprung's disease?
Ali TalebiMohammadsadegh Talebi KahdoueiElmira Hajiesmaeil MemarBahar AshjaeiHojatollah RajiMaryam Ghavami AdelPublished in: BMC research notes (2024)
In this study, 40 patients (19 males, 21 females; mean age 2.5 ± 2.2646 years) were assessed for Hirschsprung's disease. Constipation was the main symptom (75%), followed by abdominal issues. All underwent contrast enema and rectal suction biopsy for diagnosis, followed by surgery (predominantly Soave and Swensen techniques). Majority (85%) had rectosigmoid involvement. Neural fiber diameter was measured, with 52.5% ≤40 μm and 47.5% >40 μm. Statistical analysis showed 40% sensitivity(CI:95%) and 47% specificity(CI:95%) with a cutoff of 40.5 μm. Cohen's kappa index for aganglionic segment size was 0.7.
Keyphrases
- end stage renal disease
- ejection fraction
- minimally invasive
- chronic kidney disease
- newly diagnosed
- ultrasound guided
- optic nerve
- fine needle aspiration
- prognostic factors
- patients undergoing
- peritoneal dialysis
- computed tomography
- coronary artery disease
- african american
- immune response
- patient reported
- acute coronary syndrome
- toll like receptor
- surgical site infection
- optical coherence tomography