Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy.

Daniel S KikuchiAna Carolina P CamposHongyan QuSteven J ForresterRosana L PaganoBernard LassègueRuxana T SadikotKathy K GriendlingMarina Sorrentino Hernandes

Published in: Journal of neuroinflammation (2019)

These data suggest Poldip2 mediates LPS-induced BBB disruption by regulating NF-κΒ subunit p65 activation and Cox-2 and prostaglandin E2 induction. Consequently, targeted inhibition of Poldip2 may provide clinical benefit in the prevention of sepsis-induced BBB disruption.

Keyphrases

blood brain barrier
lps induced
inflammatory response
acute kidney injury
intensive care unit
septic shock
cerebral ischemia
signaling pathway
high glucose
diabetic rats
oxidative stress
big data
machine learning
drug induced
artificial intelligence
immune response
brain injury
cell proliferation