Synthesis of Imidazoles and Oxazoles via a Palladium-Catalyzed Decarboxylative Addition/Cyclization Reaction Sequence of Aromatic Carboxylic Acids with Functionalized Aliphatic Nitriles.
Ling DaiShuling YuNingning LvXuanzeng YeYinlin ShaoZhongyan ChenJiuxi ChenPublished in: Organic letters (2021)
We herein report an efficient approach for the assembly of multiply substituted imidazoles and oxazoles in a single-step manner. These transformations are based on a decarboxylation addition and annulation of readily accessible aromatic carboxylic acids and aliphatic nitriles and exhibit good functional group compatibility and a high step economy. The reaction is scalable, and as-prepared products could be transformed into practical skeletons. Importantly, the late-stage derivatization of Momelotinib highlights the potential utility of this methodology.
Keyphrases
- amino acid
- ms ms
- high performance liquid chromatography
- molecular docking
- liquid chromatography tandem mass spectrometry
- gas chromatography mass spectrometry
- quantum dots
- liquid chromatography
- simultaneous determination
- gas chromatography
- molecularly imprinted
- tandem mass spectrometry
- solid phase extraction
- human health
- mass spectrometry