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A randomized trial comparing the efficacy and safety of treating patients with type 2 diabetes and highly elevated HbA1c levels with basal-bolus insulin or a glucagon-like peptide-1 receptor agonist plus basal insulin: The SIMPLE study.

Marconi AbreuAnna TumyanAhmed ElhassanKatherine PeicherOlivia PapacosteaPerihan DimachkieMuhammad S SiddiquiLaurentiu M PopUma GunasekaranStephen H MandyBeverley Adams-HuetXilong LiIldiko Lingvay
Published in: Diabetes, obesity & metabolism (2019)
In patients with HbA1c ≥10% treatment with GLP1RA plus basal insulin, compared with basal-bolus insulin, resulted in better glycaemic control and body weight, lower insulin dosage and hypoglycaemia, and improved quality of life. This treatment strategy is an effective and safe alternative to a basal-bolus insulin regimen.
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