Insulin/IGF1 signalling mediates the effects of β2 -adrenergic agonist on muscle proteostasis and growth.
Dawit Albieiro Pinheiro GonçalvesWilian A SilveiraLeandro H ManfrediFlávia A GraçaAndrea ArmaniEnrico BertaggiaBrian T O NeillNatalia LautherbachJuliano MachadoLeonardo NogaraMarcelo G PereiraDiletta ArcidiaconoStefano RealdonC Ronald KahnMarco SandriIsis do Carmo KettelhutLuiz Carlos Carvalho NavegantesPublished in: Journal of cachexia, sarcopenia and muscle (2019)
NS/IGF1 signalling is necessary for the anti-proteolytic and hypertrophic effects of in vivo β2 -adrenergic stimulation and appears to mediate FOR-induced enhancement of protein synthesis. INS/IGF1 signalling only partially contributes to gain in strength and does not mediate fibre type transition induced by FOR.