Pigment epithelium-derived factor (PEDF), a novel adipokine contributes to gestational diabetes mellitus (GDM).

Weiwei QiDan ZhuPing YinXiaoqiong GuZhen ZhaoMiao-Xin LiChang DongQilong TangWanting XieTi ZhouHuimin XiaXiu QiuXia YangGuoquan Gao

Published in: The Journal of clinical endocrinology and metabolism (2023)

In addition to insulin resistance and upregulated insulin levels in normal pregnancy and GDM, aberrant PEDF levels can serve as a "fingerprint" of metabolic abnormalities during pregnancy. Thus, PEDF is a valuable biomarker but could interfere with the time course for early diagnosis and prognosis of GDM.

Keyphrases

insulin resistance
type diabetes
pregnancy outcomes
pregnant women
adipose tissue
metabolic syndrome
preterm birth
glycemic control
high fat diet
skeletal muscle
polycystic ovary syndrome