Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice.

Fatemeh AshrafianShahrbanoo Keshavarz Azizi RaftarArezou LariArefeh ShahryariSara AbdollahiyanHamid Reza MoradiMorteza MasoumiMehdi DavariShohreh KhatamiMir Davood OmraniFarzam VaziriAndrea MasottiSeyed Davar Siadat

Published in: Microbial cell factories (2021)

Pasteurized A. muciniphila and its EVs, as paraprobiotic and postbiotic agents, were found to play a key role in the regulation of metabolic functions to prevent obesity, probably by affecting the gut-adipose-liver axis.

Keyphrases

high fat diet induced
insulin resistance
metabolic syndrome
weight loss
human milk
induced apoptosis
type diabetes
weight gain
adipose tissue
cell cycle arrest
skeletal muscle
high glucose
diabetic rats
body mass index
low birth weight
preterm infants
wild type