Independent component analysis reveals 49 independently modulated gene sets within the global transcriptional regulatory architecture of multidrug-resistant Acinetobacter baumannii .
Nitasha D MenonSaugat PoudelAnand V SastryKevin RychelRichard SzubinNicholas DillonHannah TsunemotoYujiro HiroseBipin G NairGeetha B KumarBernhard O PalssonVictor NizetPublished in: mSystems (2024)
's transcriptional regulatory network architecture can provide much-needed context for a comprehensive understanding of pathogenesis and virulence, as well as for the development of targeted therapies that modulate these pathways.
Keyphrases
- acinetobacter baumannii
- multidrug resistant
- transcription factor
- pseudomonas aeruginosa
- drug resistant
- gram negative
- genome wide identification
- gene expression
- escherichia coli
- biofilm formation
- klebsiella pneumoniae
- staphylococcus aureus
- cystic fibrosis
- copy number
- antimicrobial resistance
- heat shock
- oxidative stress
- genome wide analysis