NDM-1 Carbapenemase-Producing Enterobacteriaceae are Highly Susceptible to Ceragenins CSA-13, CSA-44, and CSA-131.
Sylwia Joanna ChmielewskaKarol SkłodowskiEwelina PiktelŁukasz SuprewiczKrzysztof FiedorukTamara DanilukPrzemyslaw Karol WolakPaul B SavageRobert BuckiPublished in: Infection and drug resistance (2020)
Development of ceragenins should be viewed as one of the valid strategies to provide new treatment options against infections associated with CPE. The studies presented herein demonstrate that NDM-1-positive bacteria are more susceptible to ceragenins than to conventional antibiotics. In effect, CSA-13, CSA-44, and CSA-131 may be favorable for prevention and decrease of global burden of CPE.