Germline investigation in male breast cancer of DNA repair genes by next-generation sequencing.
R ScarpittaI ZannaP AretiniG GambinoC ScatenaB MeiM GhilliE RossettiM RoncellaC CongregatiF BonciA G NaccaratoD PalliMaria Adelaide CaligoPublished in: Breast cancer research and treatment (2019)
As expected, a positive family history is a strong predictor of germline BRCA2 mutations in male BC. Understanding the potential pathogenicity of VUS represents an extremely urgent need for the management of BC risk in Male BC cases and their own families.