Simvastatin protects photoreceptors from oxidative stress induced by all-trans-retinal, through the up-regulation of interphotoreceptor retinoid binding protein.

Ting ZhangMark GilliesYing WangWeiyong ShenBobak BahramiShaoxue ZengMeidong ZhuWenjuan YaoFanfan ZhouMichael MurrayKe WangLing Zhu

Published in: British journal of pharmacology (2019)

Our findings suggest that simvastatin has a novel role in protecting photoreceptors from atRAL-induced stress. Simvastatin treatment resulted in up-regulation of IRBP and its upstream transcription factor CRX in Y79 cells, ex vivo human retinal explants, and murine retinas in vivo. Further studies of simvastatin to treat photoreceptor degeneration are warranted.

Keyphrases

oxidative stress
induced apoptosis
transcription factor
optical coherence tomography
binding protein
diabetic rats
diabetic retinopathy
endothelial cells
high glucose
cell cycle arrest
dna damage
endoplasmic reticulum stress
induced pluripotent stem cells
signaling pathway
combination therapy
heat stress