Clinical outcomes associated with sarcomere mutations in hypertrophic cardiomyopathy: a meta-analysis on 7675 individuals.

Farbod Sedaghat-HamedaniElham KayvanpourOguz Firat TugrulAlan LaiAli AmrJan HaasTanja ProctorPhilipp EhlermannKatrin JensenHugo A KatusBenjamin Meder

Published in: Clinical research in cardiology : official journal of the German Cardiac Society (2017)

A pooled dataset and a comprehensive genotype-phenotype analysis show that the age at disease onset of HCM patients with MYH7 is earlier and leads to a more severe phenotype than in patient without such mutations. Furthermore, patients with sarcomeric mutations are more susceptible to SCD. The present study further supports the clinical interpretation of sarcomeric mutations in HCM patients.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
end stage renal disease
chronic kidney disease
newly diagnosed
heart failure
early onset
clinical trial
atrial fibrillation
patient reported outcomes