Intranasal administration of Acinetobacter lwoffii in a murine model of asthma induces IL-6-mediated protection associated with caecal microbiota changes.
Bilal Alashkar AlhamweZhan GaoFahd AlhamdanHani HarbMatthieu PicheneAbel GarnierJihad El AndariAndreas KaufmannPeter L GraumannDörthe KesperChristian DaviaudHolger GarnJorg TostDaniel P PotaczekMartin J BlaserHarald RenzPublished in: Allergy (2022)
These experiments provide a novel mechanism of Acinetobacter lwoffii-induced asthma protection operating through IL-6-mediated epigenetic activation of IL-10 production and with associated effects on the intestinal microbiome.