Vascular neutrophilic inflammation and immunothrombosis distinguish severe COVID-19 from influenza pneumonia.

Leo Nicolai Alexander LeunigSophia BrambsRainer W J KaiserMarkus JoppichMarie-Louise HoffknechtChristoph GoldAnouk EngelVivien PolewkaMaximilian MuenchhoffJohannes C HellmuthAdrian RuhleStephan LedderoseTobias WeinbergerHeiko SchulzClemens SchererMartina RudeliusMichael ZollerOliver T KepplerBernhard ZwißlerMichael von Bergwelt-BaildonStefan KääbRalf ZimmerRoman D BülowRoman David BülowPeter BoorSteffen MassbergKami Pekayvaz Konstantin Stark

Published in: Journal of thrombosis and haemostasis : JTH (2020)

Our data underline an innate immune cell axis causing vascular inflammation and immunothrombosis in severe SARS-CoV-2 infection.

Keyphrases

oxidative stress
immune response
coronavirus disease
early onset
sars cov
respiratory syndrome coronavirus
electronic health record
drug induced
big data
artificial intelligence
respiratory failure