Login / Signup

First-trimester screening for trisomies by cfDNA testing of maternal blood in singleton and twin pregnancies: factors affecting test failure.

S GalevaMaría Del Mar GilL KonstantinidouRanjit AkolekarK H Nicolaides
Published in: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology (2020)
Maternal age, weight, racial origin and parity, gestational age, dichorionicity, method of conception and serum levels of free β-hCG and PAPP-A are independent predictors of cfDNA test failure. The risk of test failure is higher in dichorionic twin than in singleton pregnancies, mainly because a higher proportion of twins are conceived by in-vitro fertilization and more of the women are nulliparous. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.
Keyphrases
  • gestational age
  • birth weight
  • preterm birth
  • pregnancy outcomes
  • weight gain
  • body mass index
  • weight loss
  • pregnant women
  • adipose tissue
  • systematic review
  • metabolic syndrome
  • african american
  • meta analyses