Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism.
Fabrizio PinRafael BarretoMarion E CouchAndrea BonettoThomas M O'ConnellPublished in: Journal of cachexia, sarcopenia and muscle (2019)
The results of this study demonstrated for the first time that cancer-induced and chemotherapy-induced cachexia is characterized by a number of distinct metabolic derangements. Effective therapeutic interventions for cancer-induced and chemotherapy-induced cachexia must take into account the specific metabolic defects imposed by the pathological or pharmacological drivers of cachexia.