Comparison of whole blood cytokine immunoassays for rapid, functional immune phenotyping in critically ill patients with sepsis.

Anthony S BonaviaAbigail SamuelsenMenglu LiangJodi HansonDaniel McKeoneZissis C ChroneosE Scott Halstead

Published in: Intensive care medicine experimental (2023)

Our study affirms the feasibility of obtaining dependable immune phenotyping data within 6 h of blood collection from critically ill patients, both septic and non-septic, using the ELLA immunoassay. Both ELLA and ELISpot can offer valuable insights into prognosis, therapeutic strategies, and the underlying mechanisms of sepsis development.

Keyphrases

acute kidney injury
high throughput
intensive care unit
septic shock
electronic health record
big data
machine learning
sensitive detection
artificial intelligence
data analysis
quantum dots