Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue.
Matthew DevallRebecca G SmithAaron JeffriesEilis HannonMatthew N DaviesLeonard SchalkwykJonathan MillMichael WeedonKatie LunnonPublished in: Clinical epigenetics (2017)
Our study represents a comprehensive analysis of the mitochondrial methylome using pre-existing Methylated DNA Immunoprecipitation Sequencing data to identify brain region-specific patterns of mitochondrial DNA methylation.
Keyphrases
- dna methylation
- oxidative stress
- genome wide
- resting state
- white matter
- gene expression
- endothelial cells
- cerebral ischemia
- circulating tumor
- functional connectivity
- electronic health record
- induced pluripotent stem cells
- cell free
- copy number
- brain injury
- machine learning
- artificial intelligence
- deep learning
- high throughput sequencing