Association of Arachidonic Acid-Derived Lipid Mediators With Disease Severity in Patients With Relapsing and Progressive Multiple Sclerosis.
Jelle Y BroosFloor C LoonstraLodewijk R J de RuiterMariam M T E E GoudaWing Hee FungMenno Michiel SchoonheimMarieke HeijinkEva M M StrijbisCharlotte E TeunissenJoep KillesteinHelga E de VriesMartin A GieraBernard M J UitdehaagGijs KooijPublished in: Neurology (2023)
In PwMS of the same birth year, we show that ω-3 and -6 LMs are associated with disability, biochemical (sNfL, GFAP) and MRI measures. Furthermore, our findings indicate that particularly in patients with PMS, elevated levels of specific products of the AA pathway, such as 15-HETE, associate with neurodegenerative processes. Our findings highlight the potential relevance of ω-6 LMs in the pathogenesis of MS.