Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease.
Jillian K LeeSheelakumari RaghavanLuke R ChristensonRyan D FrankKejal KantarciWalter A RoccaPrashanthi VemuriMichelle M MielkePublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Hormonal contraception use was associated with better brain white matter (WM) integrity. Initiation of menopausal hormone therapy >5 years post menopause was associated with worsening brain WM integrity. Hormonal contraception use was associated with greater cortical thickness. Ages at menarche and menopause and number of pregnancies were not associated with imaging measures. There were few associations between reproductive factors or exogenous estrogens and amyloid or tau PET.
Keyphrases
- white matter
- multiple sclerosis
- resting state
- postmenopausal women
- polycystic ovary syndrome
- high resolution
- computed tomography
- cognitive decline
- optical coherence tomography
- type diabetes
- positron emission tomography
- stem cells
- preterm birth
- skeletal muscle
- gestational age
- cerebral ischemia
- blood brain barrier
- mass spectrometry
- metabolic syndrome
- pregnancy outcomes