Dihydrotestosterone induces arterial stiffening in female mice.
Alec C HortonMary M WilkinsonIsabella Kilanowski-DorohZhejun DongJiao LiuBenard O OgolaBruna VisniauskasSarah H LindseyPublished in: Biology of sex differences (2024)
These findings indicate that androgen promotes arterial stiffening and cardiovascular damage in female mice and is associated with decreased estrogen receptor expression. These data are important for transgender men, women using testosterone for fitness or reduced libido, as well as patients with polycystic ovarian syndrome.
Keyphrases
- high fat diet induced
- polycystic ovary syndrome
- body composition
- physical activity
- electronic health record
- insulin resistance
- type diabetes
- replacement therapy
- middle aged
- wild type
- machine learning
- pregnancy outcomes
- hepatitis c virus
- pregnant women
- hiv infected
- hiv testing
- artificial intelligence
- human immunodeficiency virus
- antiretroviral therapy