Leishmania braziliensis prostaglandin F2α synthase impacts host infection.

Eliza Vanessa Carneiro Alves-FerreiraTiago Rodrigues FerreiraPegine WalradPaul M KayeAngela Kaysel Cruz

Published in: Parasites & vectors (2020)

LbrPGF2S, a parasite-derived protein, is targeted to the host cell cytoplasm. The putative transfer of this enzyme, involved in pro-inflammatory lipid mediator synthesis, to the host cell suggests a potential role in host-parasite interaction and may partially explain the increased pathogenicity associated with overexpression of LbrPGF2S in L. braziliensis. Our data provide valuable insights to help understand the importance of parasite-derived lipid mediators in pathogenesis.

Keyphrases

single cell
plasmodium falciparum
toxoplasma gondii
cell therapy
trypanosoma cruzi
transcription factor
cell proliferation
escherichia coli
life cycle
big data
mesenchymal stem cells
small molecule
drug delivery
artificial intelligence
cystic fibrosis
data analysis
disease virus