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FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.
Xiao-Na Zhu
Yu-Sheng Wei
Qian Yang
Hao-Ran Liu
Zhe Zhi
Di Zhu
Li Xia
Deng-Li Hong
Yun Yu
Guo-Qiang Chen
Published in:
Journal of hematology & oncology (2023)
FBXO22 promotes MLLr AML progression by targeting BACH1 and targeting FBXO22 might be an ideal strategy to eradicate LSCs without influencing normal hematopoiesis.
Keyphrases
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acute myeloid leukemia
allogeneic hematopoietic stem cell transplantation
cancer therapy
small molecule