Paroxetine ameliorates prodromal emotional dysfunction and late-onset memory deficit in Alzheimer's disease mice.

Peng-Hui AiSi ChenXian-Dong LiuXiao-Na ZhuYuan-Bo PanDong-Fu FengShengdi ChenNan-Jie XuSuya Sun

Published in: Translational neurodegeneration (2020)

Our data indicate that prophylactic administration of paroxetine ameliorates the emotional dysfunction and memory deficit in AD mice. These neuroprotective effects are attributable to functional restoration of glutamate receptor (GluN2A) in AD mice.

Keyphrases

late onset
high fat diet induced
early onset
oxidative stress
working memory
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wild type
type diabetes
insulin resistance
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electronic health record
metabolic syndrome
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