An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men.
Sandro C EstevesDaniele SantiManuela SimoniPublished in: Andrology (2019)
Current evidence supports interventional therapy as a means to alleviate sperm DNA damage. Identification of the conditions associated with SDF remains important to enable treatment to potentially improve pregnancy outcomes but given the limited data further research is needed to determine the exact role of specific interventional therapy for subfertile men with impaired sperm chromatin.
Keyphrases
- dna damage
- pregnancy outcomes
- pregnant women
- oxidative stress
- dna repair
- physical activity
- electronic health record
- cell free
- single molecule
- transcription factor
- polycystic ovary syndrome
- genome wide
- density functional theory
- big data
- machine learning
- adipose tissue
- mesenchymal stem cells
- bone marrow
- cell therapy
- data analysis
- artificial intelligence