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Thyroid replacement therapy, thyroid stimulating hormone concentrations, and long term health outcomes in patients with hypothyroidism: longitudinal study.

Rasiah ThayakaranNicola J AdderleyChristopher SainsburyBarbara TorlinskaKristien BoelaertDana ŠumiloMalcolm PriceG Neil ThomasKonstantinos A ToulisKrishnarajah Nirantharakumar
Published in: BMJ (Clinical research ed.) (2019)
In patients with a diagnosis of hypothyroidism, no evidence was found to suggest a clinically meaningful difference in the pattern of long term health outcomes (all cause mortality, atrial fibrillation, ischaemic heart disease, heart failure, stroke/transient ischaemic attack, fractures) when TSH concentrations were within recommended normal limits. Evidence was found for adverse health outcomes when TSH concentration is outside this range, particularly above the upper reference value.
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