Evaluation of an Injectable, Solid-State, Oxygen-Delivering Compound (Ox66) in a Rodent Model of Pulmonary Dysfunction-Induced Hypoxia.

Danuel A CarrWilliam H Nugent Bjorn K Song Bjorn K Song

Published in: Military medicine (2022)

Treatment with intravenous Ox66 improved interstitial oxygenation in the spinotrapezius muscle-a recognized bellwether for systemic capillary function-suggesting an improvement in oxygen delivery. Ox66 offers a novel approach to supplemental oxygenation that bypasses lung injury and dysfunction.

Keyphrases

solid state
oxidative stress
low density lipoprotein
high glucose
diabetic rats
pulmonary hypertension
blood flow
skeletal muscle
endothelial cells
high dose
drug induced
hyaluronic acid