Abnormal DNA methylation within HPA-axis genes years after paediatric critical illness.

Grégoire Coppens Ilse Vanhorebeek Fabian GüizaInge DeresePieter J WoutersGreet Van den Berghe Karolijn Dulfer Koenraad F M Joosten Sascha C A T Verbruggen Greet Van den Berghe

Published in: Clinical epigenetics (2024)

Two years after critical illness in children, abnormal methylation within HPA-axis genes was present, predominantly within FKBP5 and AKR1D1, partly attributable to glucocorticoid treatment in the PICU, and explaining part of the long-term developmental impairments. These data call for caution regarding liberal glucocorticoid use in the PICU.

Keyphrases

genome wide
dna methylation
gene expression
young adults
genome wide identification
intensive care unit
emergency department
copy number
electronic health record
machine learning
data analysis
smoking cessation