Ligand-binding Domain-activating Mutations of ESR1 Rewire Cellular Metabolism of Breast Cancer Cells.
Lotem ZingerKeren Merenbakh-LaminAnat KleinAdi ElazarShani JournoTomer BoldesMetsada Pasmanik-ChorAvishay SpitzerTami RubinekIdo WolfPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
Taken together, these data indicate estrogen-independent rewiring of breast cancer cell metabolism by LBD-activating mutations. These unique metabolic activities may serve as a potential vulnerability and aid in the development of novel treatment strategies to overcome endocrine resistance.