Cytosolic 5'-nucleotidase 1A autoantibody profile and clinical characteristics in inclusion body myositis.
James B LillekerA RietveldS R PyeK MariampillaiO BenvenisteM T J PeetersJ A L MillerM G HannaP M MachadoM J PartonK R GheorgheU A BadrisingI E LundbergS SacconiM K HerbertN J McHughB R F LeckyC BrierleyD Hilton-JonesJ A LambM E RobertsR G CooperC G J SarisG J M PruijnH ChinoyB G M van Engelennull nullPublished in: Annals of the rheumatic diseases (2017)
Differences were observed in clinical and histopathological features between anticytosolic 5'-nucleotidase 1A antibody positive and negative patients with inclusion body myositis, and antibody-positive patients had a higher adjusted mortality risk. Stratification of inclusion body myositis by anticytosolic 5'-nucleotidase 1A antibody status may be useful, potentially highlighting a distinct inclusion body myositis subtype with a more severe phenotype.