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MiR-1224-5p Activates Autophagy, Cell Invasion and Inhibits Epithelial-to-Mesenchymal Transition in Osteosarcoma Cells by Directly Targeting PLK1 Through PI3K/AKT/mTOR Signaling Pathway.

Bicheng JinDongfang JinZhaozhen ZhuoBo ZhangKun Chen
Published in: OncoTargets and therapy (2020)
MiR-1224-5p targets PLK1 to inhibit PI3K/AKT/mTOR signaling pathway, thus mediating the proliferation, invasion, apoptosis, autophagy and EMT in OS cells.
Keyphrases
  • signaling pathway
  • induced apoptosis
  • cell cycle arrest
  • endoplasmic reticulum stress
  • pi k akt
  • cell death
  • oxidative stress
  • epithelial mesenchymal transition
  • cancer therapy