Alpha 1 Antitrypsin is an Inhibitor of the SARS-CoV-2-Priming Protease TMPRSS2.

Nurit P AzouzAndrea M KlinglerVictoria CallahanIvan V AkhrymukKatarina ElezLluís RaichBrandon M HenryJustin L BenoitStefanie W BenoitFrank NoéKylene Kehn-HallMarc E Rothenberg

Published in: Pathogens & immunity (2021)

Our data support the key role of extracellular serine proteases in SARS CoV-2 infections and indicate that treatment with serpins, particularly the FDA-approved drug A1AT, may be effective in limiting SARS-CoV-2 dissemination by affecting the surface of the host cells.

Keyphrases

sars cov
respiratory syndrome coronavirus
induced apoptosis
electronic health record
big data
machine learning
smoking cessation
combination therapy
deep learning
protein kinase