In vivo imaging of early stages of rheumatoid arthritis by α5β1-integrin-targeted positron emission tomography.
Johannes NotniFlorian T GassertKatja SteigerPeter SommerWilko WeichertErnst J RummenyMarkus SchwaigerHorst KesslerReinhard MeierMelanie A KimmPublished in: EJNMMI research (2019)
α5β1-integrin PET could add a new functional imaging aspect to the portfolio of RA diagnostics because it appears to be a sensitive biomarker for early RA development. We suggest α5β1-integrin PET as a valuable tool to achieve a higher precision for early diagnosis of RA, including initial staging, monitoring of the disease course, and drug treatment, and for planning of radiosynoviorthesis (RSO).
Keyphrases
- positron emission tomography
- rheumatoid arthritis
- computed tomography
- pet ct
- disease activity
- high resolution
- pet imaging
- ankylosing spondylitis
- interstitial lung disease
- systemic lupus erythematosus
- cell adhesion
- cell migration
- drug delivery
- idiopathic pulmonary fibrosis
- mass spectrometry
- drug induced
- replacement therapy