Pharmacodynamic and pharmacokinetic profile of SM-1, a triple-drug combination to increase total sleep time.

Thomas A DahlLan Bo ChenMika ScheininJaana Suopanki-LalowskiMarju ValgeAntti PuhakkaHannu MikolaZsófia LovróAxel MeierjohannLauri VuorilehtoThomas Roth

Published in: Human psychopharmacology (2019)

SM-1 was well tolerated and has pharmacologic activity starting within an hour of ingestion, lasting approximately 7-8 hr. Sedative activity was seen with subjective, psychomotor, and electroencephalography assays.

Keyphrases

sleep quality
blood pressure
emergency department
single cell