All-trans retinoic acid exhibits anti-proliferative and differentiating activity in Merkel cell carcinoma cells via retinoid pathway modulation.

Chiara MazziottaGiada BadialeChristian Felice CervelleraGiampaolo MorcianoGiulia Di MauroAntoine TouzéPaolo PintonMauro TognonFernanda Martini John Charles Rotondo

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2024)

These results underline the potential of retinoid-based therapy for MCC management and might open the way to novel experimental approaches with other retinoids and/or combinatorial treatments.

Keyphrases

induced apoptosis
cell cycle arrest
minimally invasive
endoplasmic reticulum stress
cell death
signaling pathway
risk assessment
human health
oxidative stress
magnetic resonance
magnetic resonance imaging
cell proliferation
contrast enhanced
computed tomography
climate change
pi k akt