The pro-inflammatory cytokine TNF-α inhibits lymphatic pumping via activation of the NF-κB-iNOS signaling pathway.
Yingxuan ChenSonia RehalSimon RoizesHai-Lei ZhuWilliam C ColePierre-Yves von der WeidPublished in: Microcirculation (New York, N.Y. : 1994) (2018)
These findings suggest that TNF-α decreases mesenteric lymphatic contractility by activating the NF-κB-iNOS signaling pathway. This mechanism could contribute to the alteration of lymphatic pumping reported in intestinal inflammation.