The microsomal triglyceride transfer protein inhibitor lomitapide improves vascular function in mice with obesity.
Undral MunkhsaikhanYoungin KwonAmal M SahyounKarima Ait-AissaAdam KassanModar KassanPublished in: Obesity (Silver Spring, Md.) (2022)
Treatment with lomitapide attenuated the increase in body weight in mice with obesity and restored the lipid profile and vascular function. These effects were accompanied by a decrease in inflammation and oxidative stress.