Inflammatory aspects of Alzheimer's disease.
Pablo Botella LucenaMichael T HenekaPublished in: Acta neuropathologica (2024)
Alzheimer´s disease (AD) stands out as the most common chronic neurodegenerative disorder. AD is characterized by progressive cognitive decline and memory loss, with neurodegeneration as its primary pathological feature. The role of neuroinflammation in the disease course has become a focus of intense research. While microglia, the brain's resident macrophages, have been pivotal to study central immune inflammation, recent evidence underscores the contributions of other cellular entities to the neuroinflammatory process. In this article, we review the inflammatory role of microglia and astrocytes, focusing on their interactions with AD's core pathologies, amyloid beta deposition, and tau tangle formation. Additionally, we also discuss how different modes of regulated cell death in AD may impact the chronic neuroinflammatory environment. This review aims to highlight the evolving landscape of neuroinflammatory research in AD and underscores the importance of considering multiple cellular contributors when developing new therapeutic strategies.
Keyphrases
- cognitive decline
- cell death
- mild cognitive impairment
- oxidative stress
- inflammatory response
- multiple sclerosis
- machine learning
- traumatic brain injury
- lipopolysaccharide induced
- neuropathic pain
- deep learning
- spinal cord injury
- cognitive impairment
- lps induced
- subarachnoid hemorrhage
- cerebrospinal fluid
- functional connectivity
- resting state