Effect of N-methyl-D-aspartate-receptor-enhancing agents on cognition in patients with schizophrenia: A systematic review and meta-analysis of double-blind randomised controlled trials.

Chun-Hung Chang Hsien-Yuan LanePing-Tao TsengShaw-Ji ChenChieh-Yu LiuChieh-Hsin Lin

Published in: Journal of psychopharmacology (Oxford, England) (2019)

Our meta-analysis revealed no significant effect of NMDA-enhancing agents on overall cognition. However, subgroup analysis suggested that NMDAR-enhancing agents may benefit young patients with schizophrenia, and NAC may have an effect on working memory. Additional trials with larger samples are suggested to evaluate these cognitive domains and ascertain the possible mechanisms.

Keyphrases

working memory
systematic review
mild cognitive impairment
double blind
white matter
attention deficit hyperactivity disorder
single cell
study protocol
multiple sclerosis