Combining Genetic Variants to Improve Risk Prediction for NAFLD and Its Progression to Cirrhosis: A Proof of Concept Study.

Umberto Vespasiani-GentilucciChiara Dell'UntoAntonio De VincentisAndrea BaiocchiniMarco Delle MonacheRoberto CecereAdriano Maria PellicelliValerio GiannelliSimone CarottiGiovanni GalatiPaolo GalloFrancesco ValentiniFranca Del NonnoDavide RosatiSergio MoriniRaffaele Antonelli-IncalziAntonio Picardi

Published in: Canadian journal of gastroenterology & hepatology (2018)

The effects determined by disease-associated variants at different loci can add up to multiply the risk of NAFLD and NASH-cirrhosis. Combining different disease-associated variants may represent the way for genetics to keep strength in NAFLD diagnostics.

Keyphrases

copy number
gene expression