Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE -mutated tumors.
Hee Sang HwangDeokhoon KimJene ChoiPublished in: Journal for immunotherapy of cancer (2022)
mutations occurring via MMR deficiency within MSI-high tumors may have combined pathogenic roles. A mutated PI3K/AKT/mTOR pathway may be a biomarker that can be used to stratify patients with advanced MSI-high tumors for immune therapy.