Unraveling the Effects of Acute Inflammation on Pharmacokinetics: A Model-Based Analysis Focusing on Renal Glomerular Filtration Rate and Cytochrome P450 3A4-Mediated Metabolism.

Feiyan LiuLinda B S AulinMartijn L MansonElke H J KrekelsJ G Coen van Hasselt

Published in: European journal of drug metabolism and pharmacokinetics (2023)

This analysis demonstrates differences in the impact of inflammation on drug clearance for different drug types. The effects of inflammation status on pharmacokinetics may explain the inter-individual variability in pharmacokinetics in critically ill patients. The proposed model-based analysis may be used to further evaluate the effect of inflammation, i.e., by incorporating the effect of inflammation on other drug-metabolizing enzymes or physiological processes.

Keyphrases

oxidative stress
emergency department
adverse drug