IL-33 Promotes ST2-Dependent Fibroblast Maturation via P38 and TGF-β in a Mouse Model of Epidural Fibrosis.

Haoran WangTao WuFeng HuaJinpeng SunYunfeng BaiWeishun WangJun LiuMingshun Zhang

Published in: Tissue engineering and regenerative medicine (2022)

In summary, IL-33/ST2 promoted fibroblast differentiation into myofibroblasts via MAPK p38 and TGF-β in a mouse model of epidural fibrosis after laminectomy.

Keyphrases

mouse model
spinal cord
transforming growth factor
signaling pathway
oxidative stress
epithelial mesenchymal transition
liver fibrosis
wound healing
spinal cord injury
cell proliferation