Safety and efficacy of intravenous thrombolysis in patients with acute ischemic stroke taking direct oral anticoagulants prior to stroke: a meta-analysis.

Huo LiangXue WangXuemei QuanBin QinJian ZhangShuolin LiangZhijian Liang

Published in: Journal of neurology (2023)

The meta-analysis indicated that taking DOACs prior to stroke does not significantly increase the risk of sICH in selected patients with AIS treated with IVT. Furthermore, the benefits of IVT in selected patients taking DOACs appear to be comparable to those not taking anticoagulants. Further research is warranted to confirm the findings.

Keyphrases

direct oral anticoagulants
acute ischemic stroke
atrial fibrillation
venous thromboembolism
systematic review
end stage renal disease
newly diagnosed
chronic kidney disease
peritoneal dialysis
pulmonary embolism
meta analyses
low dose
prognostic factors
patient reported